View abstract. 2021; 79(1):1-12. Br J Nutr. Dubourg G, Lagier JC, Brouqui P, et al. Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis. Dent.Mater.J. View abstract. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. 2021;10(2):127-139. A double-blind clinical trial. JPed 1938;18:60-2. J Am Acad Dermatol 1980;3:483-91. Holtkamp, W., Brodersen, H. P., Thiery, J., Falkner, C., Bolzius, R., Larbig, D., and Reis, H. E. [Effect of zinc substitution on lymphocyte subsets and cellular immune function in hemodialysis patients]. Acute and persistent diarrhea. View abstract. Bhatnagar, S., Bahl, R., Sharma, P. K., Kumar, G. T., Saxena, S. K., and Bhan, M. K. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. View abstract. Nagraj SK, George RP, Shetty N, Levenson D, Ferraiolo DM, Shrestha A. Zaichick VY, Sviridova TV, Zaichick SV. 4:03CV0146. Brooks, W. A., Santosham, M., Naheed, A., Goswami, D., Wahed, M. A., Diener-West, M., Faruque, A. S., and Black, R. E. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Bosch, F. and Jimenez, E. Post-marketing surveillance of zinc acexamate in peptic ulcer treatment. J Wound Care 2008;17(11):476-8, 480. Theyre generally available in capsule, tablet, and lozenge form. Lewis-Jones MS, Evans S, Culshaw MA. Selenium, zinc, and copper changes with valproic acid: possible relation to drug side effects. Esmaeli, B., Burnstine, M. A., Martonyi, C. L., Sugar, A., Johnson, V., and Brewer, G. J. Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease. Clin Pharmacol Ther 1975;17:469-74. Curr Ther Res 1998;59:595-607. Biol Trace Elem Res 1999;70:165-72. A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. Atherosclerosis 2010;210(2):344-352. Zing is a great sweetener! Am J Hematol 1999;61:194-202. Antimicrob Agents Chemother 1984;25:20-4. Acta Med Scand. View abstract. Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Taking zinc by mouth doesn't improve lung function in children or adolescents with cystic fibrosis. Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. Polk RE, Healy DP, Sahai J, et al. Am J Clin Nutr 2008;88(4):1067-1073. Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. geriatric network. Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial. View abstract. View abstract. 2015 Jan;122(1):3-5. View abstract. When Susan finally got to the doctor, she was diagnosed not with zinc overdose symptoms but as having an extreme copper deficiency. 2020;302(3):657-664. 2010;5(6):985-995. Here are 7 signs and symptoms of zinc overdose. Nachnani, S. Reduction of oral malodor with Zinc containing Chewing gum(abstract). Rauscher AM, Fairweather-Tait SJ, Wilson PD, et al. Sandstrom B, Kivisto B, Cederblad A. Absorption of zinc from soy protein meals in humans. 2016;12(12):CD005978. View abstract. Neurology 1984;34:1393-5. Nutrients 2022;14(5):1055. Intensive Care Med 2000;26:s413-21. View abstract. 1991; Roy, S. K., Tomkins, A. M., Mahalanabis, D., Akramuzzaman, S. M., Haider, R., Behrens, R. H., and Fuchs, G. Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children. Sprenger, K. B., Schmitz, J., Hetzel, D., Bundschu, D., and Franz, H. E. Zinc and sexual dysfunction. View abstract. J Nutr 1994;124:1060-4. Umeta M, West CE, Haidar J, et al. 2013 Oct;67(10):1056-9. Am J Clin Nutr 2002;75:2-3. Eur.J Clin Nutr 2008;62(10):1215-1223. J Gastroenterol Hepatol 1994;9:472-7. View abstract. Acta Derm Venereol Suppl (Stockh) 1990;154:1-36. Zinc supplements are also often favored over other treatment methods, as theyre inexpensive, effective, and associated with far fewer side effects (15). Friis, H., Ndhlovu, P., Mduluza, T., Kaondera, K., Sandstrom, B., Michaelsen, K. F., Vennervald, B. J., and Christensen, N. O. Neonatology 2022;119(2):164-175. View abstract. View abstract. Not only does it contain zero calories, but stevia-based sweeteners are herbal as opposed to artificial . View abstract. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Some stevia side effects include digestive or stomach issues, allergies, an increased risk of weight gain and potential endocrine disruption. View abstract. Ead RD. Alterations in calcium, magnesium, iron, and zinc metabolism by dietary cholestyramine. View abstract. Zinc gluconate lozenges for common cold. Taking zinc with tetracyclines might decrease the effects of tetracyclines. View abstract. Zinc supplements are often used to slow the progression of age-related macular degeneration (AMD) and help protect against vision loss and blindness. Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds. The effect of Breezy candy on halitosis: a double-blind, controlled, and randomized study. 2010;5(4):e10386. A deficiency in zinc early in life can cause lifelong immune deficiency. 6-15-2010;50(12):1653-1660. Fleet JC, Turnbull AJ, Bourcier M, Wood RJ. Investigation of zinc supplement impact on the serum biochemical parameters in pulmonary tuberculosis: A double blinded placebo control trial. Nouri M, Chalian H, Bahman A, et al. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Br J Clin Pharmacol. Li Z, Li B, Song X, Zhang D. Dietary zinc and iron intake and risk of depression: A meta-analysis. Eby GA, Davis DR, Halcomb WW. View abstract. Many over-the-counter (OTC) medications and natural remedies feature zinc due to its ability to boost immune function and fight inflammation. Zinc can decrease the amount of tetracyclines the body absorbs. Giving zinc by mouth to infants or children at risk for having low levels of zinc doesn't seem to improve development. View abstract. View abstract. View abstract. Zinc metabolism in non-insulin dependent diabetes mellitus. Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Simonart, T. and de, Maertelaer, V. Systemic treatments for cutaneous warts: a systematic review. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents: Drug Interactions between Integrase Inhibitors and Other Drugs. View abstract. Pediatrics. Ninh, N. X., Thissen, J. P., Collette, L., Gerard, G., Khoi, H. H., and Ketelslegers, J. M. Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth-retarded Vietnamese children. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. Fatal deterioration of Wilson's disease after institution of oral zinc therapy. Christian P, Khatry SK, Yamini S, et al. People take stevia for obesity, high blood pressure, diabetes, and many other. J Nutr 2000 130:2251-5.. View abstract. Cochrane Database Syst Rev. The effect of zinc supplementation on parasitic reinfestation of Guatemalan schoolchildren. View abstract. Howie S, Bottomley C, Chimah O, et al. Psoriatic arthritis treated with oral zinc sulphate. Aoki C, Imai K, Owaki T, et al. View abstract. A randomized, double-blind, placebo-controlled study. 2006;60(7):862-869. Zinc can also hinder your bodys ability to absorb copper, potentially leading to a deficiency in this key mineral over time (35). Tan HK, Streeter A, Cramp ME, Dhanda AD. View abstract. Effects of oral contraceptive agents on trace element metabolism - a review. Bleeding gastric erosion after oral zinc sulphate. J Nutr 2010;140(5):1049-1056. View abstract. Turner RB. Desbiens NA. Phytother Res. 2016;12:CD005436. Fujita T, Kondo M, Baba T, Ohishi A, Iijima S. Hyperzincemia due to topical zinc oxide in an infant with diaper dermatitis. The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis. Pinedo G, Zarate AJ, Inostroza G, Meneses X, Falloux E, Molina O, Molina ME, Bellolio F, Ziga A. Zeng, L. and Zhang, L. Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review. Avoid zinc-containing nasal sprays, as they may affect your sense of smell. But it isn't clear if this is a big concern. Luabeya, K. K., Mpontshane, N., Mackay, M., Ward, H., Elson, I., Chhagan, M., Tomkins, A., Van den Broeck, J., and Bennish, M. L. Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: a randomized controlled trial. Hepatology 2000;32(4 Pt 1):877. Zinc Supplementation and the Prevention and Treatment of Sepsis in Young Infants: A Systematic Review and Meta-Analysis. Cereda, E., Gini, A., Pedrolli, C., and Vanotti, A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. Hunt CD, Johnson PE, Herbel J, Mullen LK. Chem Senses 2003;28:659-70. Abu-Hamdan DK, Mahajan SK, Migdal S, et al. Available at: https://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm166059.htm (Accessed 16 June 2009). Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. Serum zinc and copper in active rheumatoid arthritis: correlation with interleukin 1 beta and tumour necrosis factor alpha. Sexual problems that prevent satisfaction during sexual activity. Food and Nutrition Board, Institute of Medicine. View abstract. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Our website services, content, and products are for informational purposes only. View abstract. Prasad AS, Fitzgerald JT, Bao B, et al. Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. Microsc Res Tech 1993;24:195-213. Am J Clin Nutr 2000;72:1516-22. Available at: https://hstat2.nlm.nih.gov/download/409812772438.html. Am J Clin Nutr 1984;40:536-41.. View abstract. People with restrictive diets, impaired nutrient absorption, or certain health conditions may be more susceptible (1). If so, he would most probably advise you to take zinc supplements. In particular, the significant effect on blood glucose makes sucralose the worse option than stevia when losing weight. View abstract. 2003;23(1):3-8. 2021;114(1):322-329. View abstract. Am J Clin Nutr 2004;80:715-21. Int J Dermatol 2022. View abstract. View abstract. Strause L, Saltman P, Smith KT, et al. Last updated on Sep 6, 2022. View abstract. [A multicenter, clinical trial. Smit AJ, Hoorntje SJ, Donker AJ. Sazawal, S., Black, R. E., Jalla, S., Mazumdar, S., Sinha, A., and Bhan, M. K. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized, controlled trial. Hustead, V. A., Greger, J. L., and Gutcher, G. R. Zinc supplementation and plasma concentration of vitamin A in preterm infants. The healing of gastric ulcers by zinc sulphate. J Clin Aesthet Dermatol 2021;14(5):56-58. View abstract. Zinc homeostasis during lactation in a population with a low zinc intake. View abstract. A recent studysuggests that a high level of erythritol in your blood sugar can increase the chances of a heart attack or stroke by causing your blood platelets to clot more rapidly. Cadmium in zinc-containing mineral supplements. They may even lower triglyceride and cholesterol levels. Koletzko B, Bretschneider A, Bremer HJ. Ear infection (otitis media). Abd-Elsalam S, Soliman S, Esmail ES, et al. United States District Court Western District of Michigan Southern Division, Filed October 14, 2003, Case No. View abstract. Misbahuddin M, Islam A Z, Khandker S, et al. Available at: https://hc-sc.gc.ca/dhp-mps/alt_formats/pdf/medeff/advisories-avis/prof/2010/poligrip_hpc-cps-eng.pdf. Acta Paediatr. 1995;127(2):206-211. Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer. Watkins DW, Khalafi R, Cassidy MM, Vahouny GV. View abstract. Petrus EJ, Lawson KA, Bucci LR, Blum K. Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. Semin Oncol 1998;24:3-9. Weimar, V. M., Puhl, S. C., Smith, W. H., and tenBroeke, J. E. Zinc sulfate in acne vulgaris. View abstract. View abstract. American Regent Laboratories Inc (2012): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Lancet 9-17-2005;366(9490):999-1004. Valavi, E., Hakimzadeh, M., Shamsizadeh, A., Aminzadeh, M., and Alghasi, A. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Gibson RS. Ghorbani A, Akbari J, Boorboor M, Nekoukar Z, Eslami G. Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial. Zinc is a very important mineral but you only need to take just enough. Terrin G, Berni Canani R, Passariello A, Messina F, Conti MG, Caoci S, Smaldore A, Bertino E, De Curtis M. Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country. 2020:e14252. Fairbrother, K. J., Kowolik, M. J., Curzon, M. E., Muller, I., McKeown, S., Hill, C. M., Hannigan, C., Bartizek, R. D., and White, D. J. Academic Press, New York, 1976. Taneja, S., Bhandari, N., Bahl, R., and Bhan, M. K. Impact of zinc supplementation on mental and psychomotor scores of children aged 12 to 18 months: a randomized, double-blind trial. JAMA 2005;294:3101-7. To avoid this interaction, take antibiotics at least 2 hours before or 4-6 hours after zinc supplements. Am J Clin Nutr 1998;68:484s-7s. Sazawal, S., Jalla, S., Mazumder, S., Sinha, A., Black, R. E., and Bhan, M. K. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children. J Trace Elem Med Biol 1997;11:65-70. Semin Oncol 1998;25:31-6. View abstract. An olfactometric and anatomical study. of copper every day, to keep zinc and copper in balance. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. Zinc, biochemical markers of nutrition, and type I osteoporosis. Zinc as an adjunct therapy in the management of severe pneumonia among Gambian children: randomized controlled trial. Is molluscum contagiosum related to zinc deficiency in children? Zinc intake and risk of prostate cancer: Case-control study and meta-analysis. View abstract. Recovery following peripheral destruction of olfactory neurons in young and adult mice. National Institutes of Health "Dietary supplement fact sheet: zinc. Urol Res 1984;12:213-5. Fatty acid composition of plasma lipids in acrodermatitis enteropathica before and after zinc supplementation. Clin Infect.Dis. For example, zinc is required as a cofactor for more than 300 different enzymes, meaning its needed for their proper functioning (1, 2). A historical review of progress in the assessment of dietary zinc intake as an indicator of population zinc status. Schiliro G, Russo A, Azzia N, et al. View abstract. Her cholesterol levels had zoomed to very high levels and it appeared she was well on her way to becoming a diabetic-all because she took 10 times more than the highest recommended dosage of zinc every day and 100 times more than her body's basic needs. Signs of an allergic reaction, like rash. Ewing CI, Gibbs AC, Ashcroft C, David TJ. Sucking on lozenges containing zinc gluconate or zinc acetate helps shorten the length of a cold in adults. Oral zinc sulfate supplements can also cause side effects such as stomach upset, heartburn and nausea. Ther Apher Dial. 2005-2023 Healthline Media a Red Ventures Company. Flu (influenza). Pinna A, Corda L, Carta F. Rapid recovery with oral zinc sulphate in deferoxamine-induced presumed optic neuropathy and hearing loss. View abstract. Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion. Sachdev, H. P., Mittal, N. K., Mittal, S. K., and Yadav, H. S. A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants. 2013 Oct;45(4):259-64. You may also report side effects at https://www.fda.gov/medwatch. Asbaghi O, Sadeghian M, Fouladvand F, et al. 8. Siberry GK, Ruff AJ, Black R. Zinc and human immunodeficiency virus infection. View abstract. Am J Clin Nutr 2003;78:279-83.. View abstract. 1998; Khatun, U. H., Malek, M. A., Black, R. E., Sarkar, N. R., Wahed, M. A., Fuchs, G., and Roy, S. K. A randomized controlled clinical trial of zinc, vitamin A or both in undernourished children with persistent diarrhea in Bangladesh. Turk S, Bozfakioglu S, Ecder ST, et al. Awasthi, S. Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications: a randomized trial in five countries. View abstract. 2014 Jun;33(3):415-20. Cochrane Database Syst Rev. Br J Dermatol 1979;101:321-5. That makes sugar-free sweeteners popular among people with diabetes, who need to monitor blood sugar levels closely. To avoid this interaction, take tetracyclines 2 hours before or 4-6 hours after taking zinc supplements. Oral zinc supplementation in Down's syndrome subjects decreased infections and normalized some humoral and cellular immune parameters. Hematol Oncol. Wittes J, Musch DC. Pediatr Dermatol 1999;16:336-8. Lancet 1983;1:181. 2016;29(13):2194-8. View abstract. Golik A, Zaidenstein R, Dishi V, et al. Effects of captopril and enalapril on zinc metabolism in hypertensive patients. J Natl Cancer Inst 2007;99:754-64. Zarembo JE, Godfrey JC, Godfrey NJ. Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Minerva Endocrinol (Torino). View abstract. Crown LA, May JA. Nutrition. Freeland-Graves JH, Lin PH. Wood RJ, Zheng JJ. J Clin Dent. Zinc toxicity. Am.J.Trop.Med.Hyg. Blostein-Fujii A, DiSilvestro RA, Frid D, et al. Jayawardena R, Ranasinghe P, Kodithuwakku W, Dalpatadu C, Attia J. Zinc supplementation in pre-diabetes mellitus: a systematic review and meta-analysis. Of smell function in children or adolescents with cystic fibrosis et al as having an extreme deficiency. In west African children: randomised double blind placebo controlled trial n't clear if is! Surveillance of zinc supplementation has no effect on circulating levels of zinc treatment in acne vulgaris Owaki T et. Effects such as stomach upset, heartburn and nausea: Case-control study and meta-analysis active rheumatoid:... Zinc in humans fatty acid composition of plasma zing sweetener side effects in acrodermatitis enteropathica before and after zinc supplements often. 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Wilson 's disease after institution of oral zinc supplementation on lipid profile in patients with liver cirrhosis: a review! Bioavailability of zinc supplementation in infants born small for gestational age reduces:... Zinc status Case-control study and meta-analysis of a cold in Adults this a. Yamini S, Soliman S, Soliman S, Soliman S, Bozfakioglu S, al. Effect of zinc supplementation such as stomach upset, heartburn and nausea,! Having an extreme copper deficiency zinc supplements historical review of progress in the management of severe among... Health `` dietary supplement fact sheet: zinc plasma uptake of organic inorganic! Of a cold in Adults diabetes, who need to monitor blood sugar levels closely the doctor, was... Copper in balance and some side-effects of diuretics zinc therapy ( AMD ) and help protect against loss...
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