Thanks. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Safety. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. I cannot express how happy I was to come across this article, so thank you for writing it! Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. As with everything else, monitor your dog for symptoms. Fleas were treated with effifax, active ingredient fipronil. Hello! I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Great summary! SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. I went back and edited my comment for consistency. Thank you for your article. I took them both to the vet for minor problems, a sore ear and a minor abscess. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Any of the above scenarios can cause real problems due to an unintended overdose. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Thanks much for the info before I bought anything! I'm planning to go on a camping trip mid-September and my vet prescribed a simparica trio tablet to make sure he's safe from fleas and ticks. Best of luck with your girl! One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. Or is it when given together? I really do not know what to do and get no real input from my Vet. How can I prevent my dog from getting ticks? Please tell me if I am wrong. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Hi there , thank you for putting this information up! Second, Id like to ask a question if you dont mind. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Select in Checkout If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Happy to help! This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Remember she is fixed. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. The main goal of this medication, according to the FDA, is; Simparica Trio 11.1-22 lbs. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. The login page will open in a new tab. 50% Off First Repeat Delivery. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Thanks! All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Este perfect pentru caini! We love her. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. Simparica. collies. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. And safe travels to you and Lola in the future. I chose Frontline Plus for him as it seems to be an older, safer spot-on. Congratulations on the new kitten. Opioid pain relievers are essential drugs, and appear safe if used with care. (I have to give them baths with a very mild or medicated shampoo.) One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Whats the best safest flea tick treatment for a collie puppy? Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. FREE delivery Tue, Mar 7. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . Im happy to hear it and so glad it helped! Nothing could be done for them. Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? Thanks again for your time : ), Thank you for pointing that out! Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). I was using Seresto collars and am on the hunt for something else. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Enjoy your girl! I doubt it as he was on leash and Im always watching him. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Is credelio considered safe when using interceptor? Frontline Gold and Frontline Shield. Hope this helps! He loves the taste of Simparica Trio and it's like a treat . Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). SIMPARICA TRIO tested positive for heartworm disease. Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. Please keep me updated if you think of it! For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. My question is about Capstar. And thank you for saying so. I am going to try WonderCide as recommended by my Vet for fleas. Thank you for all the research, it was all so helpful. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . . Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. My pleasure! The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. (Of course, skin irritation can happen with any topical product.) I didnt see the link for the drug compatibility. Is Simparica trio safe for dogs with the MDR1 gene? Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. Happy to be of help! I grew up in Michigan, and we always discontinued pest products during the cold season. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. In FL resistance is bad, and we split our time between FL & NJ. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. So, what do you think of Parastar Plus? Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . Simparica Trio (133) 133 Reviews | Answered Questions. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. , Emily, thanks for a very helpful and informative article. It was very frightening. The majority of canines will be fine, but there are enough who will react. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. Please tell me which is the safest! In effect, its like a canine-safe version of Ibuprofen, and it really did help her. Evoluciona. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Best of luck with your girl. Her treatment plan included taking him off Nexgard, and the seizures stopped. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. My two cats were father and son so probably carried the same gene. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Thank you for the reminder! Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Unfortunately, the fleas are fighting back. Seven Collies sound like a lot of work but also very wonderful! Hope this helps! Additionally, it can also be given to cats and even pregnant or nursing animals. Four Simparica Trio-treated dogs were negative for both antigen and . -It is long-lasting and provides protection against fleas for up to 35 days. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. Thank you thank you thank you for this article. In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. , Thanks for the reply! I found it extremely helpful & educational. We do eat it! Hes just a puppy himself and was already started on Interceptor and Credelio. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. I gave a mini aussie and a minnie aussie/border collie mix. All but one (5 of 6) of the Simparica Trio-treated dogs were negative for D. immitis antigen and MF on day 180, while the remaining dog was positive for the antigen but negative for MF for this day. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. So now I dont know where to turn and its almost time for his monthly treatment again. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. All Rights Reserved. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Thank you for bringing this to my attention! Appreciated!!! Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. Thank you! Simparica trio prescribed to 10 wk aussie pup. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). For years she was taking Sentinel for both heart-worm and tick prevention. (Theres also a hyperlink to her article.) I just quote the ones who are knowledgeable about MDR1. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Thank you for the positive feedback. Thank you for the warning. Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation.
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